Tag Archive for: sapien

Metastatic Lung Cancer-Finding cure starts with awareness

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Having lung cancer or a history of lung cancer, is the cause for lung cancer metastases. Cancer that metastasizes to the lungs is a life-threatening condition that develops when cancer in another area of the body (primary organ such as breast), spreads to the lung. Prevention of metastatic lung cancer can be done by avoiding the risk factors of primary lung cancer such as smoking or chewing tobacco, or prompt and successful treatment of your primary cancer. Awareness, early detection and timely treatment are vital for preventing the spread of lung cancer.

October is Ovarian cancer awareness month also

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All female cancers are not PINK. Ovarian cancer is the seventh most common cancer in women worldwide. In India, it is the 3rd leading site of cancer in women. Ovarian cancer is usually diagnosed at late stages, hence disease-free and long term survival is low. This month is devoted to raising awareness for breast and ovarian cancers and get them diagnosed at an early stage to improve treatment outcomes.

The largest category of breast cancers are hormone receptor (HR) positive. These comprise 55-60% of all breast cancers globally as well as in India. Unlike triple negative breast cancer (TNBC), HR positive breast cancers respond well to personalized treatment with newer drugs and have a high chance of successful treatment and long-term survival even in advanced stages. Hence it is important to get them diagnosed and typed for HR positivity early on and tailor the treatment for each patient.

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20-30% of patients with potentially curable breast cancer develop metastasis, denying breast cancer samurais the high quality and length of life. We need to dedicate ourselves to understanding the molecular mechanism underlying Metastatic Breast Cancer which will help identify personalized screening and treatment approaches to fight metastasis

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Breast cancer remains a significant societal, clinical and scientific challenge. It is very crucial to understand the epidemiology, epi/genetics, molecular pathology, cell and protein biology and the influence of hormones on its development and progression. Breast cancer remains the leading cancer in Indian women and worldwide hence raising awareness for risk factors and early detection is critical to increase the quantity and quality of life.

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Lymphomas are cancers that develop in the lymphatic system. Typical symptoms start with fever, swelling of some lymph nodes, weight loss, tiredness. The affected lymph nodes could be in the neck, armpit, groin, tonsils, stomach, small intestine. Once a cancer begins in one part of the lymphatic system, it can spread rapidly to other lymph nodes so early diagnosis is important. Diagnosis is done by PET or CT scan and/or biopsy, as suggested by a doctor. The incidence of lymphomas is ~5-7% among all childhood cancers. It is 2-3 time more common in boys than in girls. In India, lymphoma was reported to be the 2nd most common cancer in young boys.

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Resources:   https://www.worldchildcancer.org/, https://www.indiancancersociety.org/, https://www.acco.org/childhood-lymphomas/, https://www.childrenwithcancer.org.uk/, https://curechildhoodcancer.org/, https://lymphoma-action.org.uk/types-lymphoma-lymphoma-children-and-young-people/lymphoma-children

Kidney cancer rarely affects children. The most common one is Wilms’ tumor, also called nephroblastoma, that accounts for up to 95% of childhood kidney cancers, with most children being below the age of 5 years. It is a fast growing tumor that can spread (metastasize). It is usually treated by surgery, followed by radiation and chemotherapy. Commonly used chemo drugs are doxorubicin, vincristine and actinomycin D. Overall survival rates tend to be high (>90%), with favourable histopathology diagnosis and timely treatment.

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https://www.indiacancersurgerysite.com/wilms-tumor-treatment-india.html

September is Childhood Cancer Awareness Month. 30,000 children in India and 10 times that number worldwide develop cancer every year. There is a lack of awareness and timely diagnosis to treat them. Sapien will be sharing the Indian cancer data it has throughout September, starting with colorectal cancer.

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Resources: https://www.worldchildcancer.org/, https://www.indiancancersociety.org/, https://www.childrenwithcancer.org.uk/, https://curechildhoodcancer.org/,

Sapien’s breast cancer database showcased @BioAsia2020, shortlisted by an expert selection committee for Startup Stage @ BioAsia 2020.

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Sapien Biosciences team @ BioAsia 2020, at Stall # S14. Sapien was selected from the Startup Stage competition and awarded free exhibit space and delegate pass at BioAsia. Here we showcased several breast cancer patients’ tissue-derived in vitro models for testing new drugs and markers at Sapien. The deep database of ~10,000 Indian breast cancer patients’ data was also showcased. These data can be used for developing Artificial Intelligence-based algorithms to improve the diagnosis, treatment and survival of future breast cancer patients.