Pediatric gliomas

Individuals below the age of 18 years are susceptible to #pediatriccancer and so #pediatriccancerawareness is paramount. Many different treatment options are available including #radiotherapy, #chemotherapy, and surgery based on the type of #cancer and disease severity. Excellent follow up care both by family, #survivorship clinics and organizations such as Pediatric Brain Tumor Consortium, Pediatric Brain Tumor Foundation, and others will restore a healthy life to those affected.

American Brain Tumor Association, 

Children’s Brain Tumor Foundation

International Brain Tumour Alliance

A Kids’ Brain Tumor Cure Foundation (PLGA Foundation)

National Brain Tumor Society

Pediatric Brain Tumor Foundation

ABC2 (Accelerate Brain Cancer Cure)

Targeted therapy in Gliomas based on genetic screening ?

Mutations and mutation analysis in cancer are very useful for specific #therapies that target the #mutations and spare normal cells. #precisionmedicine, especially #precisiononcology is a well-established option for #cancertreatment. With novel therapies and #therapeutics being discovered with increasing frequency, the treatment options available for combating cancers are increasingly dependent on #genomicmedicine. With adequate #cancerawareness and #cancercare along with a helping hand, defeating this deadly disease has never looked more promising.

 

American Brain Tumor Association, 

Children’s Brain Tumor Foundation

International Brain Tumour Alliance

A Kids’ Brain Tumor Cure Foundation (PLGA Foundation)

National Brain Tumor Society

Pediatric Brain Tumor Foundation

ABC2 (Accelerate Brain Cancer Cure)

Grade and Age distribution of Brain Cancers

#glioma is a malignant cancer of the brain. Early signs include decline in brain function, #memoryloss, personality changes, Vision changes etc. Based on the type of cell affected, they are classified as, Ependymoma, Astrocytoma, Oligodendroglioma, and mixed (Oligoastrocytoma). Their #histopathology grading is based on #worldhealthorganization classification into four grades: Biologically benign gliomas [WHO grade I], Low-grade gliomas [WHO grade II] (well-differentiated and not anaplastic), and High-grade [WHO grades III–IV] (undifferentiated or anaplastic). #Sapienbio inventory has all grades of #gliomas with maximum being Grade IV or #glioblastoma.

#biobank
https://glioblastomafoundation.org/
https://www.mayoclinic.org/diseases-conditions/brain-tumor/symptoms-causes/syc-20350084
https://www.healthline.com/health/brain-tumor-charities-making-difference

May is Brain cancer awareness month

According to Global Cancer Observatory (www.gco.iarc.fr), #braincancer contributed to 2.4% of all cancers in India during 2020. They ranked 14th in the number of cases (31,460), but 10th in the number of deaths (26656) due to cancers in 2020.
To tackle this deadly cancer, Sapien has collated FFPE blocks, flash frozen #tissue, live primary cells from many #braintumors to enable #drugscreening, validation of new #drugtargets and #glioma #biomarkers.
We will be sharing our brain cancer research and resources through May, starting with this slide on our #FFPE blocks with matched #RWE data from 1 of our many hospitals.

www.indiancancersociety.org; www.cancer.gov/types/brain;

Sapien selected to be showcased among TiE50 at Global TiECon2021

Thrilled to hear we have been selected as TiE50 winner for #tiecon2021. Thank you TiE Hyderabad, TiE Silicon Valley for giving #sapienbiosciences this global forum to pitch our pioneer #biobank at. Silicon Valley has among the highest concentration of #healthcare industry and #healthcareprofessionals hence most valuable to our #growthjourney and raising #growthcapital.

Appreciate #tieglobal support for guiding us to enter the competition.
Time now to prepare 3min #pitchdeck for 6th May.

Anu Chitrapu Vanita Shastri Kumar Sripadam Manasi Kumar Phani Pattamatta Sridhar Pinnapureddy Ekta Bahl Ajay Ramasubramaniam Anurag Jain Gautam Prakash Venkat Nelabhotla Dharti Arvind Desai Gennyvie Montiel Balaji Bhyravbhatla Apoorva Kumar Samia Shamim Gautam Patel Aparna Mishra Rashida Adenwala Shivani Gupta Angela Fusaro, MD, MBA Kanika Radhakrishnan Mahavir Pratap Sharma Vijay Menon TiE Boston Vivek Soni Indu Javeri Ajit Jhangiani Ajit Rangnekar Paridhi Gupta Pravin Chaturvedi Pam Randhawa Ranjan (RJ) Mathew Geetha Ramamurthy Parag Mehta Darshana Zaveri Ravi Sakhuja Anil Khurana

Colorectal cancer Awareness – Choice of surgery

Colorectal cancer, also known as bowel cancer, colon cancer, or rectal cancer, is any cancer that affects the colon and the rectum. The American Cancer Society estimate that about 1 in 21 men and 1 in 23 women in the United States will develop colorectal cancer during their lifetime. It is the second leading cause of cancer death in women, and the third for men. However, due to advances in screening techniques and improvements in treatments, the death rate from colorectal cancer has been falling. Colorectal cancer may be benign, or non-cancerous, or malignant. A malignant cancer can spread to other parts of the body and damage them.

Colorectal cancer Awareness – Preventable, Treatable, Beatable

Colorectal cancer, also known as bowel cancer, colon cancer, or rectal cancer, is any cancer that affects the colon and the rectum. The American Cancer Society estimate that about 1 in 21 men and 1 in 23 women in the United States will develop colorectal cancer during their lifetime. It is the second leading cause of cancer death in women, and the third for men. However, due to advances in screening techniques and improvements in treatments, the death rate from colorectal cancer has been falling. Colorectal cancer may be benign, or non-cancerous, or malignant. A malignant cancer can spread to other parts of the body and damage them.

Recurrence in Kidney Cancer

Kidney cancer most often spreads to lungs and bones, but it can also spread to brain, liver, and other organs. As it has no symptoms early on, it can spread before you even know you have it. Smoking tobacco doubles the risk of developing kidney cancer. Prevention of metastatic kidney cancer can be done by quitting smoking, maintaining a healthy body weight & eating a diet high in fruits & vegetables & low in fat. If cancer has not spread far, surgery may be a cure. If it has spread to other organs, then treatment like targeted therapy and Immunotherapy will be recommended.

 

 

Treatment for Kidney Cancer

Kidney cancer is most often treated with Surgery, Chemotherapy, Targeted therapy, Immunotherapy, Radiation therapy or combination of these treatments. Treatment options and recommendations depend on several factors, including the cell type and stage of cancer, possible side effects and the patient’s preferences and overall health. For most kidney cancers, surgery is the initial treatment. The goal of surgery is to remove the tumor while preserving normal kidney function. The type of surgery done to remove the tumor is Radical Nephrectomy & Partial Nephrectomy.

Types of Kidney Cancer

In India, the incidence of kidney cancer is about 2/100,000 population in males and among females, it is nearly 1/100,000 population. Renal cell carcinoma is the most common cancer type of the Kidney cancer accounting for 80 – 85 per cent. The most common sub type of RCCis Clear cell, which accounts for 75 per cent of the cases and has a better survival as compared to non – clear cell subtype (papillary & chromophobe type). The rarer subtypes are collecting duct carcinomas & renal medullary carcinomas. Oncocytoma is a slow-growing type of kidney cancer. Angiomyolipoma are the most common benign tumor but presence of epithelioid cells can lead to cancer. Renal cell carcinoma with sarcomatoid or rhabdoid features are very aggressive and have very short survival rates.