Metastatic Lung Cancer-Finding cure starts with awareness

Having lung cancer or a history of lung cancer, is the cause for lung cancer metastases. Cancer that metastasizes to the lungs is a life-threatening condition that develops when cancer in another area of the body (primary organ such as breast), spreads to the lung. Prevention of metastatic lung cancer can be done by avoiding the risk factors of primary lung cancer such as smoking or chewing tobacco, or prompt and successful treatment of your primary cancer. Awareness, early detection and timely treatment are vital for preventing the spread of lung cancer.

November is a Lung cancer awareness month

The National Cancer Registry Programme Report 2020, released by the Indian Council of Medical Research (ICMR), estimates that there will be 13.9 lakh cases of cancer in India in 2020, and this number is likely to rise to 15.7 lakh by 2025. According to the data, tobacco-related PREVENTABLE cancers will account for 27.1 per cent of India’s cancer burden.

Validating herbal, natural products and drug candidates in cancer patient cells to design optimal clinical trials.

All female cancers are not PINK. Ovarian cancer is the seventh most common cancer in women worldwide. In India, it is the 3rd leading site of cancer in women. Ovarian cancer is usually diagnosed at late stages, hence disease-free and long term survival is low. This month is devoted to raising awareness for breast and ovarian cancers and get them diagnosed at an early stage to improve treatment outcomes.

The largest category of breast cancers are hormone receptor (HR) positive. These comprise 55-60% of all breast cancers globally as well as in India. Unlike triple negative breast cancer (TNBC), HR positive breast cancers respond well to personalized treatment with newer drugs and have a high chance of successful treatment and long-term survival even in advanced stages. Hence it is important to get them diagnosed and typed for HR positivity early on and tailor the treatment for each patient.

The Forum for Breast Cancer Protection, an NGO co-founded by caring oncologists and clinicians such as the inspiring, untiring Dr. Ramesh Sarin who continues to operate at the young age of 80 and give excellent care to her breast cancer patients. Col Pant, Dr. Sangeeta Taneja, @Karuna Sharma, Dipali Bhasin are catalysts that are active in organizing informative webinars and awareness sessions. This one on the 12th October was particularly memorable in that Ms. Sonam Kalra, a renowned singer, spoke of her mother who was diagnosed of lung cancer at the most advanced stage. She was given 6 months to live, but through her positive attitude, good routine and food, family and medical support, she lived life for 8 years, composing haikus till the end! Sonam spoke movingly of her mother and her determination to fight cancer. Her mother coined the term Cancer Samurai. Sonam sang ‘ek naam, satnam’ so beautifully it gave us goosebumps. What a treat. Then came the advice on how to use affirmation and visualization to think positively to heal our body and mind by Shivani ji, sage words in her soothing voice. Close your eyes, just listen, and feel the stress fade away.

20-30% of patients with potentially curable breast cancer develop metastasis, denying breast cancer samurais the high quality and length of life. We need to dedicate ourselves to understanding the molecular mechanism underlying Metastatic Breast Cancer which will help identify personalized screening and treatment approaches to fight metastasis

Breast cancer remains a significant societal, clinical and scientific challenge. It is very crucial to understand the epidemiology, epi/genetics, molecular pathology, cell and protein biology and the influence of hormones on its development and progression. Breast cancer remains the leading cancer in Indian women and worldwide hence raising awareness for risk factors and early detection is critical to increase the quantity and quality of life.

Lymphomas are cancers that develop in the lymphatic system. Typical symptoms start with fever, swelling of some lymph nodes, weight loss, tiredness. The affected lymph nodes could be in the neck, armpit, groin, tonsils, stomach, small intestine. Once a cancer begins in one part of the lymphatic system, it can spread rapidly to other lymph nodes so early diagnosis is important. Diagnosis is done by PET or CT scan and/or biopsy, as suggested by a doctor. The incidence of lymphomas is ~5-7% among all childhood cancers. It is 2-3 time more common in boys than in girls. In India, lymphoma was reported to be the 2nd most common cancer in young boys.

Kidney cancer rarely affects children. The most common one is Wilms’ tumor, also called nephroblastoma, that accounts for up to 95% of childhood kidney cancers, with most children being below the age of 5 years. It is a fast growing tumor that can spread (metastasize). It is usually treated by surgery, followed by radiation and chemotherapy. Commonly used chemo drugs are doxorubicin, vincristine and actinomycin D. Overall survival rates tend to be high (>90%), with favourable histopathology diagnosis and timely treatment.

India accounts for 26% of the global incidence of childhood cancers

September is Childhood Cancer Awareness Month. 30,000 children in India and 10 times that number worldwide develop cancer every year. There is a lack of awareness and timely diagnosis to treat them. Sapien will be sharing the Indian cancer data it has throughout September, starting with colorectal cancer.

Patient Samples & Data – Powering Our Products & Services

August is Psoriasis awareness month so highlighting Sapien’s samples, data, services for R&D

Psoriasis has a disease prevalence of 0.44-2.8 per cent in India and 2 to 3 % worldwide. There are many gaps in research to fully understand the epidemiology, aetiology, association with comorbidities, environmental variations, that all hinder optimal delivery of healthcare services in a personalized manner. There is a need for better quality data on incidence and prevalence of psoriasis to understand better the size and distribution of the problem. http://www.apps.who.int/iris/bitstream/10665/

Sapien will be able to provide – Just what you need for your Psoriasis study

Sapien provides tailor-made biosample services adhering to IRB/IEC approved specimen collection protocols, and patient informed consent forms, and coding patient information to protect privacy.

  1. Sample types available – Blood, tissue punch samples, other biofluids.
  2. Ideal patient and sample requirements – Treated or treatment naïve, type of psoriasis, collection tubes/anticoagulant, processing e.g., blood to serum or plasma, PBMCs or DNA, quantity, molecular cellular IHC assays, H&E images
  3. Clinical Annotation – The exact type of data needed that you need – Demographic, lifestyle, diagnostic etc.
  4. Storage requirements – Specimen can be stored as per your protocol or shipped as per your instructions.

Whatever your future psoriasis research needs – An image study, AI, Digital pathology, data analysis, biomarker analysis, drugs screening – we are here to help you

  • Despite relatively high prevalence of psoriasis at 0.4 to 2.8 % in the Indian population and availability of many treatment options, India is behind in psoriasis disease management1.
  • Research done on specific ethnic backgrounds and data from one population is not a global solution. Hence it has been recommended by WHO’s global report on Psoriasis, that Psoriasis research should focus on specific ethnicity and therapeutics that are unique to a specific population 2.
  • There is an increasing demand for crucial studies addressing definitive curative therapies.

Hence, well-conducted research specific to Indian population considering the differences in genetic makeup, environmental influences and health care costs could go a long way in improving the healthcare services for the psoriasis patients 3.

  1. Thappa DM, Munisamy M. Research on psoriasis in India: Where do we stand? Indian J Med Res. 2017;146(2):147-149. doi: 10.4103/ijmr.IJMR_1296_17
  1. https://apps.who.int/iris/bitstream/handle/10665/204417/9789241565189_eng.pdf.psoriasis;jsessionid=54912784D28C9F36ECCD45471AC5775B?sequence=1
  2. Dogra S, Mahajan R. Psoriasis: Epidemiology, clinical features, co-morbidities, and clinical scoring. Indian Dermatol Online J. 2016; 7:471–80

 

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