IHC staining of cancer cases @Sapien

At Sapien Biosciences, we screen our biobanked FFPE samples using Ventana IHC systems for optimization and staining of antibodies. This allows to visualize the presence and localization of target proteins within tissue samples, supporting biomarker validation, disease characterization, and therapeutic target identification. Our digital pathology capabilities include whole-slide scanning at 40X magnification for advanced AI and ML applications.

For example, IHC staining to detect MUC1 expression. MUC1 is often overexpressed or aberrantly glycosylated in many types of cancers, including breast, ovarian, lung, and pancreatic cancers. Its presence and expression levels serve as a useful biomarker for tumor detection and characterization. MUC1 is also a promising target for cancer therapeutics, including vaccine development and monoclonal antibody therapies.