1st August – World Lung Cancer Day – Focusing on Treatment for Lung Cancer

In recognition of #WorldLungCancerDay, It is important for everyone to learn about the #riskfactors for Lung cancer along with the importance of #earlydiagnosis through #screening and timely treatment to decrease #mortality.

In cancer care, different types of doctors often work together to create a patient’s overall treatment plan that combines different types of treatments. This is called a multidisciplinary team.

There are 5 main treatment options : i) Surgery, ii) #Radiationtherapy, iii) #Chemotherapy, iv) Targeted therapy   v) #Immunotherapy

#Surgery includes #Lobectomy, Wedge resection, Segmentectomy, #Pneumonectomy.

#Chemotherapy is the use of #drugs to destroy cancer cells, usually by keeping the cancer cells from growing, dividing, and making more cells. It has been shown to improve both the length and quality of life for people with lung cancer of all stages. Targeted therapy is a #treatment that targets the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. This type of treatment blocks the growth and spread of cancer cells and limits damage to healthy cells. Immunotherapy, also called biologic therapy, is designed to boost the body’s natural defenses to fight the cancer. It uses material made either by the body or in a laboratory to improve, target, or restore immune system function.

showcase of Prostate cancer inventory at Sapien

Prostate cancer is the most common gender specific cancer. Prostate is the second leading site of cancer among males in large Indian cities like Delhi, Kolkata, Pune and Thiruvananthapuram, third leading site of cancer in cities like Bangalore and Mumbai. According to the Indian Council of Medical Research (ICMR) and various state cancer registries, prostate cancer is the second most common form of cancer among Indian males with an incidence rate of nine to 10 per 1,00,000 population, which is higher than Africa and other parts of Asia . Almost 75% of men diagnosed with prostatic cancer are 65 or older, but the tumors can be seen in younger adults and even in children and adolescents. Hence regular screening above the age of 60 must be done for the early signs. Early screening is the best possible way to prevent and to treat the cancer before it spreads. Screening is done by checking PSA levels, and/or MRI, Ultrasound or biopsy along with physical examination.

Pediatric gliomas

Individuals below the age of 18 years are susceptible to #pediatriccancer and so #pediatriccancerawareness is paramount. Many different treatment options are available including #radiotherapy, #chemotherapy, and surgery based on the type of #cancer and disease severity. Excellent follow up care both by family, #survivorship clinics and organizations such as Pediatric Brain Tumor Consortium, Pediatric Brain Tumor Foundation, and others will restore a healthy life to those affected.

American Brain Tumor Association, 

Children’s Brain Tumor Foundation

International Brain Tumour Alliance

A Kids’ Brain Tumor Cure Foundation (PLGA Foundation)

National Brain Tumor Society

Pediatric Brain Tumor Foundation

ABC2 (Accelerate Brain Cancer Cure)

Targeted therapy in Gliomas based on genetic screening ?

Mutations and mutation analysis in cancer are very useful for specific #therapies that target the #mutations and spare normal cells. #precisionmedicine, especially #precisiononcology is a well-established option for #cancertreatment. With novel therapies and #therapeutics being discovered with increasing frequency, the treatment options available for combating cancers are increasingly dependent on #genomicmedicine. With adequate #cancerawareness and #cancercare along with a helping hand, defeating this deadly disease has never looked more promising.

 

American Brain Tumor Association, 

Children’s Brain Tumor Foundation

International Brain Tumour Alliance

A Kids’ Brain Tumor Cure Foundation (PLGA Foundation)

National Brain Tumor Society

Pediatric Brain Tumor Foundation

ABC2 (Accelerate Brain Cancer Cure)

Grade and Age distribution of Brain Cancers

#glioma is a malignant cancer of the brain. Early signs include decline in brain function, #memoryloss, personality changes, Vision changes etc. Based on the type of cell affected, they are classified as, Ependymoma, Astrocytoma, Oligodendroglioma, and mixed (Oligoastrocytoma). Their #histopathology grading is based on #worldhealthorganization classification into four grades: Biologically benign gliomas [WHO grade I], Low-grade gliomas [WHO grade II] (well-differentiated and not anaplastic), and High-grade [WHO grades III–IV] (undifferentiated or anaplastic). #Sapienbio inventory has all grades of #gliomas with maximum being Grade IV or #glioblastoma.

#biobank
https://glioblastomafoundation.org/
https://www.mayoclinic.org/diseases-conditions/brain-tumor/symptoms-causes/syc-20350084
https://www.healthline.com/health/brain-tumor-charities-making-difference

May is Brain cancer awareness month

According to Global Cancer Observatory (www.gco.iarc.fr), #braincancer contributed to 2.4% of all cancers in India during 2020. They ranked 14th in the number of cases (31,460), but 10th in the number of deaths (26656) due to cancers in 2020.
To tackle this deadly cancer, Sapien has collated FFPE blocks, flash frozen #tissue, live primary cells from many #braintumors to enable #drugscreening, validation of new #drugtargets and #glioma #biomarkers.
We will be sharing our brain cancer research and resources through May, starting with this slide on our #FFPE blocks with matched #RWE data from 1 of our many hospitals.

www.indiancancersociety.org; www.cancer.gov/types/brain;

Sapien selected to be showcased among TiE50 at Global TiECon2021

Thrilled to hear we have been selected as TiE50 winner for #tiecon2021. Thank you TiE Hyderabad, TiE Silicon Valley for giving #sapienbiosciences this global forum to pitch our pioneer #biobank at. Silicon Valley has among the highest concentration of #healthcare industry and #healthcareprofessionals hence most valuable to our #growthjourney and raising #growthcapital.

Appreciate #tieglobal support for guiding us to enter the competition.
Time now to prepare 3min #pitchdeck for 6th May.

Anu Chitrapu Vanita Shastri Kumar Sripadam Manasi Kumar Phani Pattamatta Sridhar Pinnapureddy Ekta Bahl Ajay Ramasubramaniam Anurag Jain Gautam Prakash Venkat Nelabhotla Dharti Arvind Desai Gennyvie Montiel Balaji Bhyravbhatla Apoorva Kumar Samia Shamim Gautam Patel Aparna Mishra Rashida Adenwala Shivani Gupta Angela Fusaro, MD, MBA Kanika Radhakrishnan Mahavir Pratap Sharma Vijay Menon TiE Boston Vivek Soni Indu Javeri Ajit Jhangiani Ajit Rangnekar Paridhi Gupta Pravin Chaturvedi Pam Randhawa Ranjan (RJ) Mathew Geetha Ramamurthy Parag Mehta Darshana Zaveri Ravi Sakhuja Anil Khurana

Colorectal cancer Awareness – Choice of surgery

Colorectal cancer, also known as bowel cancer, colon cancer, or rectal cancer, is any cancer that affects the colon and the rectum. The American Cancer Society estimate that about 1 in 21 men and 1 in 23 women in the United States will develop colorectal cancer during their lifetime. It is the second leading cause of cancer death in women, and the third for men. However, due to advances in screening techniques and improvements in treatments, the death rate from colorectal cancer has been falling. Colorectal cancer may be benign, or non-cancerous, or malignant. A malignant cancer can spread to other parts of the body and damage them.

Colorectal cancer Awareness – Preventable, Treatable, Beatable

Colorectal cancer, also known as bowel cancer, colon cancer, or rectal cancer, is any cancer that affects the colon and the rectum. The American Cancer Society estimate that about 1 in 21 men and 1 in 23 women in the United States will develop colorectal cancer during their lifetime. It is the second leading cause of cancer death in women, and the third for men. However, due to advances in screening techniques and improvements in treatments, the death rate from colorectal cancer has been falling. Colorectal cancer may be benign, or non-cancerous, or malignant. A malignant cancer can spread to other parts of the body and damage them.

Recurrence in Kidney Cancer

Kidney cancer most often spreads to lungs and bones, but it can also spread to brain, liver, and other organs. As it has no symptoms early on, it can spread before you even know you have it. Smoking tobacco doubles the risk of developing kidney cancer. Prevention of metastatic kidney cancer can be done by quitting smoking, maintaining a healthy body weight & eating a diet high in fruits & vegetables & low in fat. If cancer has not spread far, surgery may be a cure. If it has spread to other organs, then treatment like targeted therapy and Immunotherapy will be recommended.