Tag Archive for: biobank

Grade and Age distribution of Brain Cancers

#glioma is a malignant cancer of the brain. Early signs include decline in brain function, #memoryloss, personality changes, Vision changes etc. Based on the type of cell affected, they are classified as, Ependymoma, Astrocytoma, Oligodendroglioma, and mixed (Oligoastrocytoma). Their #histopathology grading is based on #worldhealthorganization classification into four grades: Biologically benign gliomas [WHO grade I], Low-grade gliomas [WHO grade II] (well-differentiated and not anaplastic), and High-grade [WHO grades III–IV] (undifferentiated or anaplastic). #Sapienbio inventory has all grades of #gliomas with maximum being Grade IV or #glioblastoma.

#biobank
https://glioblastomafoundation.org/
https://www.mayoclinic.org/diseases-conditions/brain-tumor/symptoms-causes/syc-20350084
https://www.healthline.com/health/brain-tumor-charities-making-difference

Recurrence in Kidney Cancer

Kidney cancer most often spreads to lungs and bones, but it can also spread to brain, liver, and other organs. As it has no symptoms early on, it can spread before you even know you have it. Smoking tobacco doubles the risk of developing kidney cancer. Prevention of metastatic kidney cancer can be done by quitting smoking, maintaining a healthy body weight & eating a diet high in fruits & vegetables & low in fat. If cancer has not spread far, surgery may be a cure. If it has spread to other organs, then treatment like targeted therapy and Immunotherapy will be recommended.

 

 

Treatment for Kidney Cancer

Kidney cancer is most often treated with Surgery, Chemotherapy, Targeted therapy, Immunotherapy, Radiation therapy or combination of these treatments. Treatment options and recommendations depend on several factors, including the cell type and stage of cancer, possible side effects and the patient’s preferences and overall health. For most kidney cancers, surgery is the initial treatment. The goal of surgery is to remove the tumor while preserving normal kidney function. The type of surgery done to remove the tumor is Radical Nephrectomy & Partial Nephrectomy.

Types of Kidney Cancer

In India, the incidence of kidney cancer is about 2/100,000 population in males and among females, it is nearly 1/100,000 population. Renal cell carcinoma is the most common cancer type of the Kidney cancer accounting for 80 – 85 per cent. The most common sub type of RCCis Clear cell, which accounts for 75 per cent of the cases and has a better survival as compared to non – clear cell subtype (papillary & chromophobe type). The rarer subtypes are collecting duct carcinomas & renal medullary carcinomas. Oncocytoma is a slow-growing type of kidney cancer. Angiomyolipoma are the most common benign tumor but presence of epithelioid cells can lead to cancer. Renal cell carcinoma with sarcomatoid or rhabdoid features are very aggressive and have very short survival rates.

Neuroendocrine Tumors

NETs encompass a heterogeneous group of tumours arising from amine-producing Neuroendocrine cells anywhere in the body. Unlike most other cancers that start in one place, NET can occur wherever there are Neuroendocrine cells in the body. Till date the treatment therapies are not well known for NET. Because of their rarity and lack of awareness, NETs are lower priority for medical #research, but NETs are not as rare as once thought and need #personalizedmedicine since no two patients are alike.

Mutations in Lung Cancer Driving Targeted Therapy

In recent years, personalized medicine has begun to bring new hope to people with lung cancer, especially non-small cell lung cancer. Personalized medicine involves looking at the cells obtained from a biopsy to see if there are any genetic mutations — changes in your genes — that could be linked to the type of cancer you have. Because certain chemotherapy drugs are either more or less effective than others against tumors with specific mutations, molecular analysis of your tumor, also called genomic testing, can help determine which therapies will be most likely to benefit you. The most common genetic changes that are tested for in lung cancer are in the genes EGFR, ALK, ROS, PDL 1 and KRAS.

Lung Cancer Surgeries – A rare route of hope

Treatment options and recommendations for lung cancer depend on several factors, including the type and stage of cancer, possible side effects, and the patient’s preferences and overall health. There are 5 main ways to treat lung cancer : Surgery, Radiation therapy, Chemotherapy, Targeted therapy, Immunotherapy. The goal of surgery is to completely remove the lung tumor and the nearby lymph nodes. The following types of surgery may be used in non small cell lung cancer, aka NSCLC: Lobectomy, A wedge resection, Segmentectomy, Pneumonectomy.

Metastatic Lung Cancer-Finding cure starts with awareness

Having lung cancer or a history of lung cancer, is the cause for lung cancer metastases. Cancer that metastasizes to the lungs is a life-threatening condition that develops when cancer in another area of the body (primary organ such as breast), spreads to the lung. Prevention of metastatic lung cancer can be done by avoiding the risk factors of primary lung cancer such as smoking or chewing tobacco, or prompt and successful treatment of your primary cancer. Awareness, early detection and timely treatment are vital for preventing the spread of lung cancer.

Job Posting for Clinical Research

October is Ovarian cancer awareness month also

All female cancers are not PINK. Ovarian cancer is the seventh most common cancer in women worldwide. In India, it is the 3rd leading site of cancer in women. Ovarian cancer is usually diagnosed at late stages, hence disease-free and long term survival is low. This month is devoted to raising awareness for breast and ovarian cancers and get them diagnosed at an early stage to improve treatment outcomes.