The NGS genotyping of our NSCLC cases using ThermoFisher’s Oncomine panel identified 8 genetic variants in the ALK gene in 9 cases (16.67%), some of which, such as G1202R and S1206Y surprisingly confer resistance to #Crizotinib treatment, but demonstrate sensitivity to second-generation ALK inhibitors such as #Brigatinib and #Ceritinib, which are currently approved for the […]
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Sapien is curating real world data for the lung cancer cases in the biobank. While 90-95% of our NSCLC samples are biopsies which are mostly exhausted in patient diagnosis and subsequent clinical #biomarker evaluation, the resection samples are being characterized genomically in Oncomine panel to correlate the demographic, diagnostic, treatment and outcomes data with genetic […]
For decades, mutations in #KRAS have been known to cause cancers in multiple organs and the gene KRAS itself was considered ‘undruggable’. Of the many mutations, KRAS-G12C is known to occur in nearly 13% of #NSCLC cases. There were no known treatments that can target KRAS-G12C mutation until recently. May 2021 heralded the #fdaapproval of […]
In recognition of #WorldLungCancerDay, It is important for everyone to learn about the #riskfactors for Lung cancer along with the importance of #earlydiagnosis through #screening and timely treatment to decrease #mortality. In cancer care, different types of doctors often work together to create a patient’s overall treatment plan that combines different types of treatments. This […]
Prostate cancer is the most common gender specific cancer. Prostate is the second leading site of cancer among males in large Indian cities like Delhi, Kolkata, Pune and Thiruvananthapuram, third leading site of cancer in cities like Bangalore and Mumbai. According to the Indian Council of Medical Research (ICMR) and various state cancer registries, prostate […]
Individuals below the age of 18 years are susceptible to #pediatriccancer and so #pediatriccancerawareness is paramount. Many different treatment options are available including #radiotherapy, #chemotherapy, and surgery based on the type of #cancer and disease severity. Excellent follow up care both by family, #survivorship clinics and organizations such as Pediatric Brain Tumor Consortium, Pediatric Brain […]
Mutations and mutation analysis in cancer are very useful for specific #therapies that target the #mutations and spare normal cells. #precisionmedicine, especially #precisiononcology is a well-established option for #cancertreatment. With novel therapies and #therapeutics being discovered with increasing frequency, the treatment options available for combating cancers are increasingly dependent on #genomicmedicine. With adequate #cancerawareness and […]
#glioma is a malignant cancer of the brain. Early signs include decline in brain function, #memoryloss, personality changes, Vision changes etc. Based on the type of cell affected, they are classified as, Ependymoma, Astrocytoma, Oligodendroglioma, and mixed (Oligoastrocytoma). Their #histopathology grading is based on #worldhealthorganization classification into four grades: Biologically benign gliomas [WHO grade I], […]
According to Global Cancer Observatory (www.gco.iarc.fr), #braincancer contributed to 2.4% of all cancers in India during 2020. They ranked 14th in the number of cases (31,460), but 10th in the number of deaths (26656) due to cancers in 2020. To tackle this deadly cancer, Sapien has collated FFPE blocks, flash frozen #tissue, live primary cells […]
Thrilled to hear we have been selected as TiE50 winner for #tiecon2021. Thank you TiE Hyderabad, TiE Silicon Valley for giving #sapienbiosciences this global forum to pitch our pioneer #biobank at. Silicon Valley has among the highest concentration of #healthcare industry and #healthcareprofessionals hence most valuable to our #growthjourney and raising #growthcapital. Appreciate #tieglobal support […]
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