Advancements in #tumor biology and prognostic #biomarkers, such as the estrogen receptor (ER), progesterone receptor (PR), HER2/neu, and Ki-67, have empowered clinicians to understand why patients with similar stages have significantly different outcomes. The 8th edition of the American Joint Committee uses nine stages (0, IA, IB, IIA, IIB, IIIA, IIIB, IIIC, and IV) based […]
Sapien’s #biorepository is expanding with the collection of fresh blood from cancer patients prior to surgery, with informed consent. The collection covers all organs, including #Breastcancer (>320 cases). The blood is processed to #plasma and #PBMCs or cell pellets. Matched #FFPE tumor blocks are also available. With 6 sites now, the #biobank is growing rapidly […]
The Sapien #biobank #Hyderabad team showed up with enthusiasm at the Grace Cancer Foundation fundraising event. Our team, along with family and friends, participated in the walk/run with full josh and walking shoes on. The well-organized event made it even more enjoyable.
Studies have shown that the risk for having breast cancer is due to a combination of factors. One of the main factors that influences the incidence of breast cancer is age, with the highest incidence rates being in older people. Most breast cancers are found in women who are 50 years or older. The American […]
Several risk factors are implicated in developing #BreastCancer in young women. Factors associated with lifestyle choices, such as physical inactivity leading obesity, excessive alcohol consumption and smoking; genetic risk factors involving mutations of breast cancer susceptibility genes such as #BRCA1 and #BRCA2; reproductive risk factors, such as age of menstruation onset, menopause can contribute to […]
Breast Cancer (BC) has surpassed lung cancer as the leading cause of cancer incidence in the world, with an estimated 2.3 million new cases, representing 11.7% of all cancer cases, with women bearing the brunt of it.In India, as per Globocan 2020 data, BC accounted for 13.5% (178,361) of all cancer cases and 10.6% (90,408) […]
Sapien has been actively collecting FFPE blocks, blood and data from #breastcancer patients in India. With over 18,000 Indian breast cancer cases from 9 cancer hospitals, Sapien has collated demographic and diagnostic datasets to aid in the fight against #breastcancer. Treatment, outcomes, genomic, biomarker and imaging data is being added to the #biobank, making early detection and optimal treatment […]
The impact of two driver mutations of RET gene, V804M/L and S891A, on Thyroid cancer was described recently by Pichardo et al in JAMA Otolaryngology, 2023. In a population screening, 75 people were identified to have 2 Pathogenic or Likely Pathogenic (P/LP) germline variants of the RET gene. 20 out of these 75 patients chose […]
Delighted to be a part of 8th Annual BGCI #conference held at the #University of Hyderabad from July 7th to 9th, 2023 where Rakesh Sharma, PhD and Madhuri R presented posters titled “Molecular landscape of #lung adenocarcinoma in India for personalizing therapy” and “Driver gene alterations in EGFR and IDH1 are mutually exclusive in Indian Gliomas”. […]
Sapien is surveying different #tumor types in its #biobank for mismatch repair-deficiency (MMR-D), also called microsatellite instability (MSi-High). This is because #colorectalcancer #patients with MMR-D do not respond well to standard #chemotherapy but do respond to immune checkpoint inhibitors or ICI. To see which other #cancers may benefit from immune checkpoint inhibitors such as #PD1, […]
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