Tag Archive for: Kidneycancer

Mismatch repair deficiency tested in seven cancer types

Sapien is surveying different #tumor types in its #biobank for mismatch repair-deficiency (MMR-D), also called microsatellite instability (MSi-High). This is because #colorectalcancer #patients with MMR-D do not respond well to standard #chemotherapy but do respond to immune checkpoint inhibitors or ICI. To see which other #cancers may benefit from immune checkpoint inhibitors such as #PD1, we tested 500 curated cases of Endometrial, H&N, Kidney, Liver, Gastric and Thyroid cancers and compared them to 165 colorectal cancers by IHC.
We observe that H&N, Liver and Thyroid cancer have low MMR-D. However, Endometrial cancers have 4-5 times higher MMR-D as compared to CRC; Stomach and Renal cancers also have 5-6% MMR-D cases. Our data suggests that immune checkpoint inhibitors may greatly improve the response rate and survival of Endometrial, Stomach and Kidney cancers in addition to CRC.

Kidney cancer rarely affects children. The most common one is Wilms’ tumor, also called nephroblastoma, that accounts for up to 95% of childhood kidney cancers, with most children being below the age of 5 years. It is a fast growing tumor that can spread (metastasize). It is usually treated by surgery, followed by radiation and chemotherapy. Commonly used chemo drugs are doxorubicin, vincristine and actinomycin D. Overall survival rates tend to be high (>90%), with favourable histopathology diagnosis and timely treatment.