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NIPER Hyderabad Pharma Industry Summit

NIPER here held a Pharma Industry Summit on 24th March 2017, bringing together many govt, academic, industry and trade groups to speak about life sciences entrepreneurship in Hyd. It was a great initiative by Dr. Nanduri who himself brings many years of industrial experience to NIPER.

I particularly enjoyed the opportunity to moderate a panel discussion on “Start Up and Entrepreneurship in Life Sciences : Challenges and Way Forward”. Our panel consisted of two academics : Dr. Suman Kapoor of BITS Pilani Hyd who has brought out a device to determine TB infection much faster, and Dr. Madhusudhan of CCMB who is currently spearheading CCMB as an incubator for Life Sciences industry.  Dr. Balaji Bhyravbhatla of Hylasco, a serial entrepreneur, Dr. Swaroop Vakkalanka of Incozen with several licensing deals under his belt, and myself as a co-founder of Sapien Biosciences represented LS Industry.

Each panelist spoke from their experience and shared some of their advice such as getting sufficient experience in one’s field before embarking on entrepreneurship, assessing your market often to manage risk, knowing your investor as well as your competitors, maintaining a diary of ideas and vetting them with experienced people, not being too possessive of one’s ideas, being willing to back out if timing is not right, forming teams of 3-4 people where 1 member is not a scientist etc.

There were many questions from the audience which made for a lively interaction.

Key action items that emerged from the panel were to

a)      Form a LS group and hold a monthly networking meeting rotating at different forums several of which were offered immediately – CCMB, BITS campus, NIPER, Madhapur. A WA group will be created soon.

b)     Create a comprehensive directory of LS companies in Hyd area

I noted that I knew all the panelists! This used to be common in LS meetings at TiE-Boston but it was nice that it finally happened in Hyderabad, a city I moved to 5 years ago.

In picture from L to R: Mr S Reddy (Registrar NIPER), Dr. S Nanduri (Professor, NIPER), Dr. J Jain (CEO, Sapien), Dr. S Vakkalanka (CEO, Incozen), Dr S Kapoor (Professor BIT Pilani Hyd), Dr. B Bhyravbhatla (CEO, Hylasco), Dr. Madhusudhan (Professor, CCMB).

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Molecular Med Tricon 2017

Dr. Jain attended the Molecular Med Tricon 2017 conference at San Francisco 19-23rd Februrary, 2017. It was a blend of academia and industry working in the field of personalized medicine using molecular approaches. Dr. Jain joined Sapien’s partner, Trans-Hit Bio of Canada, who had put up a booth at the conference and promoted our partnership jointly.

Dr. Jain attended the Diagnostics and Cancer Tracks where dozens of companies and groups working on improving the sensitivity and specificity of blood- or urine-based markers ranging from cancer cells or cell-free DNA, RNA, proteins presented new technologies. Such groups are potential customers of our biobank so it was a good meeting from business point of view as well.

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Sapien collaborates with Dr. Anjana Rao of La Jolla Institute

It is a pleasure to be working again with Dr. Anjana Rao, Jugnu’s postdoc advisor from Dana Farber Cancer Institute & Harvard Medical School days. Anjana is now the Chair of La Jolla Institute of Allergy and Immunology with a joint appointment at UCSD.  Her lab’s work on Tet family of proteins and their regulation of transcription via methylation in cancer is well known (Rao et al Nat Immunol 2017).

Given our biobank’s deep collection of annotated cancer samples, both FFPE and matched live cells,  it’s a synergistic alliance wherein Sapien brings not just samples but also its R&D expertise in histopathology, cellular and molecular biology to bear on the project.  The project’s first milestone to standardize and automate LJI’s IHC protocol in Sapien hands has been reached.

Sapien Biosciences and OncoStem Diagnostics collaborate to launch CanAssist-Breast, a Breast cancer recurrence prediction test

Hyderabad, November 10, 2016: Sapien Biosciences, a niche biotech venture committed to develop novel cutting-edge medical diagnostics backed by Apollo Hospitals Enterprise Limited announces its partnership with OncoStem Diagnostics, to launch “CanAssist-Breast”, a robust and cost-effective test to predict the risk of breast cancer recurrence in early stage hormone positive and Her2 negative Breast Cancer patients.

Sapien Biosciences is a bio-repository that enables the development of cutting edge diagnostics and therapeutics for personalizing medicine. Patient samples and associated medical data that are systematically collated and ethically banked at Sapien are a necessary resource for rapid validation of novel diagnostic tests. Announcing the partnership with OncoStem Diagnostics Dr. Jugnu Jain, Co-Founder and CEO – Sapien Biosciences said, “We are very excited to be part of this launch of CanAssist–Breast which represents a paradigm shift in customizing Breast cancer treatment. Development of accurate recurrence diagnostics in cancer is particularly dependent on the availability of reliable retrospective information which is acutely lacking in India. To validate CanAssist-Breast, we mobilized five Apollo hospitals data archives to piece together complete 5 years treatment and outcome data for over 6500 Indian breast cancer patients”.

In India, about 1,50,000 patients are diagnosed of breast cancer every year and currently there are no affordable tests to predict the risk of cancer recurring. As a result, majority of early stage patients with low risk of recurrence are perhaps over-treated and thus bear toxic effects of chemotherapy treatment (CT) that reduces their ‘quality of life’. Additionally, studies have proven that the benefit of chemotherapy in such patients is known to be 10-15% suggesting many patients can be spared conventional CT. Highlighting the importance of CanAssist-Breast, Dr. Manjiri Bakre, Founder and CEO, OncoStem Diagnostics said, “CanAssist-Breast is our flagship product and is a boon for patients as well as doctors. It enables clinicians to assess the aggressiveness of the tumor and personalize and optimize therapy for their patients. The canAssist-Breast test can spare over 60,000 Breast Cancer patients in India and over 660,000 patients worldwide every year from the severe effects and unnecessary costs of chemotherapy-associated toxic”.

CanAssist-Breast test uses clinical parameters in combination with novel biomarkers quantified using a standardized technique which measures protein expression accurately. This information is integrated into a statistical algorithm to stratify patients as “low or high risk” for recurrence. “In India, due to a variety of reasons ranging from awareness to culture, Breast Cancer patients are diagnosed much later, with only 5-8% of patients being Stage 1 at detection.  Consequently, the globally available recurrence prediction tests are not very impactful in geographies such as India and SE Asia due to their utility being limited to only Stage 1 patients and the prohibitive cost of the tests. CanAssist-Breast test can be used on a much wider pool of patients up to Stage 2B, and is priced at 1/6th the price of competitor tests and therefore aims to touch the lives of millions of patients worldwide”, added Dr Bakre.

CanAssist-Breast is being launched within the Apollo network in India and the worldwide launch is planned in a phased manner.  Commenting on the partnership, Ms. Shobana Kamineni, Executive Vice Chairperson, Apollo Hospitals says, “Affordable and broad based tests to estimate the ‘risk of recurrence’ are an absolute necessity for ‘optimal and personalized’ treatment planning. Apollo has been at the forefront of recognizing personalized medicine as the future of healthcare delivery and has been adopting cutting-edge diagnostic tests to deliver better patient care to improve outcomes. Our association with Sapien is one of various initiatives we have undertaken with a vision to enable personalized medicine approach and we are very excited to see this crystallize through partnerships such as this one with OncoStem. Cancer recurrence space is largely unexplored, especially in India and needs immediate attention. I look forward to Apollo & Sapien pioneering the introduction & adoption of this important innovation from OncoStem across our network of oncology centres for the benefit of our patients.”

CanAssist-Breast is ISO-13485 accredited, and expects to acquire the CE mark by November 2016.  These accreditations will enable the launch of the test in global markets later this year. The market for a breast cancer recurrence diagnostic space  is currently valued at $ 3 Billion globally and is expected to grow at 18% CAGR.  Clinical validation of CanAssist-Breast in India and the US demonstrates a high NPV (negative predictive value) of 95%, which is a measure of the accuracy of the test. The results of the global validation study are currently under review for publication.

About Apollo Hospitals Enterprise Ltd. (AHEL)

It was in 1983, that Dr. Prathap Reddy made a pioneering endeavor by launching India’s first corporate hospital – Apollo Hospital in Chennai. Now, as Asia largest and most trusted healthcare group, its presence includes over 8,600 beds across 50 Hospitals, 1,632 Pharmacies, 92 Primary Care and Diagnostic Clinics, 100 Telemedicine units across 10 countries. Health Insurance services, Global Projects Consultancy, 15 colleges of Nursing and Hospital Management, a Research Foundation with a focus on global Clinical Trials, epidemiological studies, genetic research and the upcoming first Proton Therapy Center across Asia, Africa and Australia.

In a rare honor, the Government of India issued a commemorative stamp in recognition of Apollo’s contribution, the first for a healthcare organization. Apollo Hospitals Chairman, Dr. Prathap C Reddy, was conferred with the prestigious Padma Vibhushan in 2010. For more than 30 years, the Apollo Hospitals Group has continuously excelled and maintained leadership in medical innovation, world-class clinical services and cutting-edge technology. Our hospitals are consistently ranked amongst the best hospitals globally for advanced medical services and research.

About Sapien Biosciences Pvt. Ltd.

Sapien Biosciences is a joint venture between Apollo Hospitals & Saarum Innovations that has created a world-class biobank and personalized medicine company that leverages Apollo’s leadership position in healthcare and Saarum’s cutting-edge life sciences research expertise for novel clinical and R&D applications. Sapien’s primary objective is to use its high-quality bio-repository that integrates ethically consented human samples with associated medical, pathological & treatment data and utilize this resource to develop & deliver high-end diagnostic applications. Further Sapien has entered into an alliance with Apollo Hospitals that allows Sapien to front-end Apollo’s personalized medicine initiatives. This allows Sapien to bring novel cutting-edge diagnostics to Apollo, either on its own or in collaboration with best-of-breed global institutions world-wide thereby enabling world-class healthcare to improve patient outcomes. Sapien has fully functional labs located within the Apollo Health City Campus in Hyderabad. For more information about Sapien Biosciences, visit www.sapienbio.com.

About OncoStem Diagnostics Pvt. Ltd. 

OncoStem is a start-up diagnostic oncology company.  It is founded by a Dr. Manjiri Bakre, a Cell Biology veteran with significant experience in US, Singapore and India in cancer biology and cancer drug discovery.  It is funded by Artiman Ventures, an early-stage Silicon Valley-based venture fund that invests in white space companies that create or disrupt multi-billion dollar markets. OncoStem is primarily focused on developing novel tests which will predict ‘risk of cancer recurrence’ and thus enable physicians to prescribe targeted drugs to prevent cancer recurrence.  OncoStem’s initial focus is breast cancer as it is the most common cancer in women across the globe but it also plans to develop similar tests for other cancers such as oral, glioma, lung and colon. For more information about OncoStem Diagnostics, visit www.oncostemdiagnostics.com

 

For more information, please contact    info@sapienbio.com , 040-65580008,  9704600772

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Human medical waste to build biobanks

http://www.journal.ijmio.com/index.php/ijmio/article/view/132

Jugnu Jain, Sreevatsa Natarajan, Soma Chatterjee

India has a high disease burden and a large number of patients. There is a tremendous need for Indian biobanks to preserve Indian samples, to capture the great diversity of diseases to spur research into earlier, more precise diagnosis and better treatments for diseases plaguing India. This review article summarizes the key components of building a systematic comprehensive biobank, type and formats of sample and data, and the ethical and regulatory guidelines in India. An example of a growing Indian biobank, Sapien Biosciences, is shared along with its business model to reach sustainability. This is done by developing clinical diagnostics internally using the annotated samples but also sharing samples and outcomes data with external investigators. Our goal is to highlight the immense untapped value of Indian biospecimens and data, to catalyze the formation of collaborative networks of biobanks both within and outside India

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Industry Internships for Motivated Biology-Based Graduate Students

Jugnu Jain
CEO at Sapien Biosciences & Saarum Sciences

We offer 2 to 12 month research internships for bright diligent motivated graduate students in Biology, Biotech, Pharmacy, Bioinformatics, Health data analytics etc. The internships can be hands-on lab experience (molecular biology, cell biology, diagnostics, FACS etc.), or in medical data analysis, sample and clinical data organization in EMR/EHR databases. Specific clinically-relevant projects focused on patient treatment paradigms e.g., breast cancer, stent procedures drugs and outcomes, cost-benefit analysis of targeted drugs are also available.

Lab-based training is available at Hyderabad, whilst data and project-based training is available at Ahmedabad, Bangalore, Bhubaneswar, Chennai, Delhi, Kolkata and other metro locations where Apollo Hospitals are present.

Appropriate ethical approval for projects involving handling of patient material or data is always taken. Students are trained in confidentiality and safety norms.

In addition to a certificate of internship and thesis, students are encouraged to present their findings in conferences. Longer-term interns that make significant contribution to projects may also be acknowledged in presentations and publications from our group. Mentoring of students aspiring for MS/PhD abroad is done on a case-by-case basis.

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Our first paper on breast cancer is accepted for publication

Jugnu Jain
CEO at Sapien Biosciences & Saarum Sciences

“Epidemiological and survival analysis of triple negative breast cancer cases in a retrospective multicentre study” comprising 257 TNBC cases collated from across five cancer centres in India has been accepted for publication. It should be out in a few months.

Next one summarizing data from >6500 Indian breast cancer cases, of all receptor types, is under preparation. Our goal is to exceed 10,000 cases within the year.

Our database of breast cancer samples, complete diagnosis and treatment info, combined with 3-5 year outcomes data offers tremendous opportunity to study Indian risk factors, identify optimal treatment paradigms for each subtype of patients, analyze cost-benefit ratio of different surgical/chemo/RT treatments, etc. We expect using them to also develop better prognostic, diagnostic and theranostic tests to improve survival in breast cancer patients.

Stay tuned!

Welcome to Sapien Biosciences

We are under construction

Please check back later for more updates

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Apollo Hospitals & Saarum Innovations launch Sapien Biosciences

Welcome to Sapienbio Blog

This article originally appeared in 2013

Joint Venture to create a world-class human bio-bank and personalized medicine company, first of its kind in India to enableinnovative research & clinical applications

Hyderabad, September 23, 2013:

Apollo Hospitals with Saarum Innovations, launched its joint venture ‘Sapien Biosciences’ today at Hyderabad to create aworld-class bio-bank and personalized medicine company. The bio-bank will comprise of collections of high-quality, ethically-consented and anonymized human samplesalong with associated medical & sample-level data across various diseases e.g., cancer, cardiovascular and diabetes. This will enable cutting-edge life sciences research and support the discovery & development of novel biomarkers, diagnostics & personalized medicine applications.Sapien plans tocollaborate with healthcare enterprises and drug discovery companies globally to study disease epidemiology, validate new diagnostics, identify new drug targets and evaluate new drugs.

Sapien has exclusive access to the entire Apollo network for its bio-banking needs but expects to partner with additional research-oriented hospitals and clinics for their personalized medicine and bio-banking needs. Further Sapien has entered into an alliance with Apollo Hospitals that allows Sapien to front-end Apollo’s personalized medicine initiatives. This allows Sapien to bring novel cutting-edge diagnostics to Apollo, either on its own or in collaboration with best-of-breed institutions world-wide thereby enabling world-class healthcare and improving patient outcomes.

Speaking on the occasion, Ms. Shobana Kamineni, Executive Director, New Initiatives, Apollo Hospitals, said, “This is a proud moment for us at Apollo to be a part of this landmark initiative in the history of Indian Health care. Apollo Hospitals has long had a vision of creating Asia’s largest bio-bank which is being realized in partnership with Saarum Innovations. Sapien will help fulfill our vision of delivering better clinical outcomes through bench-to-bedside innovation. This alliance is a further validation of Apollo’s commitment to research-driven health care.”

Speaking on the occasion Mr. Sreevatsa Natarajan, Co-founder & CEO, Sapien Biosciences said “Saarum Innovations is proud to be associated with a healthcare pioneer & leader like Apollo Hospitals. Apollo’s passion for world-class healthcare combined with Saarum Innovations’ proven research expertise will bridge healthcare & life-sciences and enable cutting-edge research & diagnostics applications.”

Speaking on the occasion, Mr. Seemant Jauhari, CEO of AHERF said, “Apollo, through the Apollo Health Education & Research Foundation (AHERF), is spearheading a vibrant portfolio of innovative projects that will enable effective and affordable technologies for better treatment outcomes. Bio-banking & personalized medicine was one such initiative which is being realized with the launch of Sapien Biosciences.

Sapien Biosciences also announces the launch of its first & novel personalized medicine test,‘myPLATELET, which determines patients’ response to their blood-thinning medicationand supports decision-making by their cardiologists to personalize therapy for better outcomes. This is the only test in India that combines both genetic and platelet function response to enable tailored anti-platelet therapy for each patient.

Speaking on the occasion Dr. Jugnu Jain, Co-founder and CSO, Sapien Biosciences said “Sapien’s novel myPLATELET test offers more complete assessment of a patient’s platelet response than existing tests and enables informed clinical decision-making thus exemplifying Sapien’s approach to personalized medicine innovation.”

About Saarum Innovations

Saarum Innovations has been set-up with the vision of utilizing human tissues, primary cells and stem cells to better understand disease biology, develop novel biomarkers and diagnostics, discover novel drug targets and drugs therapeutics that translate into better clinical successes. It is co-founded by a team of three seasoned life sciences R&D professionals,Sreevatsa Natarajan, Prithi Rajan and Jugnu Jain who collectively have over 60 years of global R&D experience.

Sapien Biosciences is managed by the Saarum Innovations team with Sreevatsa Natarajan as the Co-founder & CEO, Jugnu Jain as the Co-Founder & CSO, and Prithi Rajan as the Co-Founder & Executive Director.For more information about Sapien Biosciences, please refer www.sapienbio.com

About Apollo Hospitals

In 1983, Dr Prathap C Reddy, the architect of Indian healthcare, launched the first corporate hospital in India. An integrated healthcare company, the Apollo Hospitals Group has over 8,500 beds across 50 hospitals, more than 1200 pharmacies and 100 diagnostic clinics, medical business process outsourcing services, health insurance services, and clinical research divisions with a focus on epidemiological studies, stem cell research and genetic research. To develop talent for the burgeoning need of superior healthcare delivery, the Apollo Hospitals Group has 11 nursing and hospital management colleges. These accomplishments have earned Apollo Hospitals Group accolades such as the Centre of Excellence from the Government of India and recognition from the Joint Commission International (seven of our hospitals are JCI accredited). In a rare honor, the Government of India issued a commemorative stamp in recognition of Apollo’s contribution, the first for a health care organization. Apollo, for over 27 years, has continuously excelled and maintained leadership in medical innovation, world-class clinical services and cutting edge research. Our hospitals are consistently ranked amongst the best hospitals globally for advanced medical services. For more information visit www.apollohospitals.com

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Apollo Hospitals set to integrate clinical genomics as part of its personalized medicine initiatives

Note: This article originally appeared in September, 2013

Sapien Biosciences, an Apollo subsidiary, to spearhead the introduction of cutting-edge genomic testing across the Apollo network

Apollo Hospitals today announced the introduction of several genomic tests as part of its personalized medicine initiative. The introduction of these tests, over the next few months, shall be spearheaded by the Apollo Hospitals subsidiary, Sapien Biosciences.

Sapien was launched in Dec 2012 with the vision of being a world-class biobank and personalizedmedicine company that will bring novel diagnostics to Apollo, either on its own or in collaboration with best-of-breed institutions world-wide thereby improving patient outcomes. Previously Apollo, through Sapien, had launched – India’s first, a personalized test that combines assessment of a patients’ genotype and their platelet function to allow the physician to personalize anti-platelet therapy..
Genomic testing involves analyses of patient genomes and translating insights gained from these analyses to develop better healthcare interventions by way of better prognostic tools for improved disease screening and prevention strategies, better diagnostic tests for optimization of clinical care and better theranostic tests for personalization of treatment.

Sapien has been working with multiple genetic testing providers in India over the last few months to develop and customize these tests for introduction at Apollo. The first of these tests, to be launched shortly, shall be a clinical genomics panel for oncology that is designed to identify the mutations that drive cancer initiation and progression. Insights obtained from this test will enable prediction of patients’ response to their medication allowing the physician to tailor treatment to the patients’ genomic profile. Along with the cancer genomic panels, we will also be launching other panels that will enable differential diagnosis of certain heritable eye and cardiovascular diseases. Such panels will be especially helpful in identifying specific gene mutations in affected individuals. This information can in turn be used to screen unaffected members of their family for early detection and management.

We shall also be introducing, genetic testing within the preventive healthcare context under careful physician supervision and with appropriate genetic counseling support. Apollo has pioneered the preventive healthcare revolution in India and has, to-date, performed over 8.5 million preventive health checks. The advent of advanced genomic analytical techniques has enabled screening for genetic predisposition to various diseases. In this context, tests that identify an individual’s risk for diseases of high relevance in the Indian population (such as cardiovascular, diabetes and obesity) could make a significant clinical impact. Further genetic tests planned for roll-out include single gene panels for specific cancers (such as BRCA1/2, etc.), other disease-specific genetic testing panels (such as diabetes, autism etc.), pharmacogenetic panels (for assessment of response to specific drugs) and peri-natal diagnosis of genetic disorders.

Speaking on the occasion, Dr. Prathap C. Reddy, Chairman, Apollo Hospitals, said, “At Apollo, we believe, that such genetic tests, that are increasingly being adopted world-wide, will have a major impact on the delivery of quality clinical care and we are planning to integrate them into our clinical practice, in a manner consistent with global best practices. I am excited about the comprehensive strategy put together by Sapien to introduce genomic testing at Apollo and I look forward to the successful launch of these tests.”

Speaking on the occasion, Ms. Sangita Reddy, Executive Director, Apollo Hospitals, said, “Apollo has been a trend-setter in healthcare, pioneering the concept of preventive health checks in 1983 and the concept of Personalized Health Checks (PHCs) in 2013. Going forward, we are excited that these PHCs will include an optional genetic test to assess an individual’s risk factors for diabetes, obesity and cardiovascular disorders. Such tests will allow our clinicians to personalize their patients’ health-check follow-up and assess risk factors that can potentially impact their long-term health outcomes.”

Speaking on the occasion Mr. Sreevatsa Natarajan, Co-founder & CEO, Sapien Biosciences said “The comprehensive roadmap developed by Sapien anticipates the launch of various genetic tests over the course of the next few months across the Apollo network, in partnership with key collaborators. At Sapien, we have a highly qualified, internationally experienced team that will play a major role in the systematic roll-out and integration of genomic testing and other cutting-edge diagnostic tests at Apollo. Eventually, Sapien and Apollo’s vision shall be crystallized as centers for personalized medicine across the Apollo network”

Speaking on the occasion Dr. Jugnu Jain, Co-founder and CSO, Sapien Biosciences said “Our experience with genetics allows us to critically evaluate literature and customize tests for Indian patients for optimal clinical benefit, consistent with global best practices and patient privacy norms. Over time, we expect to have a large database of genotype-phenotype correlation for Indian patients that will allow identification and quantification of genetic risk factors, akin to a ‘Framingham Score’, for cardiovascular diseases, diabetes and cancer.”

Speaking on the occasion, Mr. Seemant Jauhari, CEO, Research & Innovations, Apollo Hospitals said, “Pushing new frontiers through healthcare innovation is a key driver at Apollo. Apollo has deliberated introducing genetic testing in a responsible and effective manner. We intend to integrate these tests into the clinical practice at our hospitals with active participation from our physicians in prescribing and interpreting test results within the context of the patients’ overall clinical profile. Further, we are considering creating a comprehensive genetic counseling course as part of Apollo’s initiatives in medical education.”